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Nanoparticles in the treatment of malignant neoplasms
https://doi.org/10.29235/1818-9857-2023-04-77-83
Abstract
The penetration of new technologies into chemistry, biology and medicine has led to the creation of new disciplines - nanotechnology and nanomedicine, branches of science in which the size of the object of study becomes critical. At the same time, the widespread application of nanoparticles in biology and medicine requires an understanding of the fundamental mechanisms of their interaction with biological systems. This is especially important for the development of new methods of treatment and diagnosis with their help. The presented review is devoted to the use of nanoparticles in the treatment of malignant neoplasms and the creation of gene therapy systems based on them. The review considers various types of nanoparticles and features of their effect on malignant neoplasms, methods and techniques for using nanoparticles for the diagnosis and treatment of cancer, as well as related problems and limitations. The characteristics of clinical preparations based on nanoparticles are presented.
About the Authors
A. Stanovaya
Институт биофизики и клеточной инженерии НАН Беларуси
Belarus
Belarus
Alesya Stanovaya
V. Zhogla
Институт биофизики и клеточной инженерии НАН Беларуси
Belarus
Belarus
Victoria Zhogla
I. Galets-Buy
Институт биофизики и клеточной инженерии НАН Беларуси
Belarus
Belarus
Inessa Galets-Buy
S. Loznikova
Государственный комитет по науке и технологиям Республики Беларусь
Belarus
Belarus
Svetlana Loznikova
D. Shcherbin
Институт биофизики и клеточной инженерии НАН Беларуси
Russian Federation
Russian Federation
Dmitry Shcherbin
References
1. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / H.Sung[etal.] // CA: acancer journal for clinicians. 2021. Vol. 71. №3. P.209–249.
2. Медведева И.В. Статистический ежегодник Республики Беларусь / редкол.: И.В. Медведева (отв. ред.) [и др.] // Национальный статистический комитет РБ.– Минск, 2020.
3. S. C. Baetke. Applications of nanoparticles for diagnosis and therapy of cancer / S.C. Baetke, T. Lammers, F. Kiessling// Br.J. Radiol. 2015. Vol. 88. №1054. Р. 20150207.
4. Radio-photothermal therapy mediated by asingle compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model / M.Zhou[etal.] // Nanoscale. 2015. Vol. 7. №46. P.19438–19447.
5. Application of nanotechnology to cancer radiotherapy/ Y. Mi [etal.] // Cancer Nanotechnol. 2016. Vol. 7. №1. Р. 11
6. Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles / K.M. Au[etal.] // ACS Nano. 2015. Vol. 9. №9. P.8976–8996.
7. Evaluation of antioxidant and anticancer activity of copper oxide nanoparticles synthesized using medicinally important plant extracts / D. Rehana[etal.] // Biomed. Pharmacother. 2017. Vol. 89. P.1067–1077.
8. Kummara S.Synthesis, characterization, biocompatible and anticancer activity of green and chemically synthesized silver nanoparticles – A comparative study/ S. Kummara, M.B.Patil, T. Uriah // Biomed. Pharmacother. 2016. Vol. 84. P.10–21.
9. Antimicrobial and anticancer activities of porous chitosan-alginate biosynthesized silver nanoparticles / J. Venkatesan [etal.] // Int. J. Biol. Macromol. 2017. Vol. 98. P.515–525.
10. The influence of maltotriose-modified poly(propylene imine) dendrimers on the chronic lymphocytic leukemia cells in vitro: Dense shell G4 PPI / I.Franiak-Pietryga[etal.] // Mol. Pharm. 2013. Vol. 10. №6. P.2490–2501.
11. Gorzkiewicz M. Dendrimers as nanocarriers for nucleoside analogues / M. Gorzkiewicz, B. Klajnert-Maculewicz // Eur. J.Pharm. Biopharm. 2017. Vol. 114. P.43–56.
12. Nanomedicine: Towards development of patient-friendly drug-delivery systems for oncological applications / R. Ranganathan [etal.] // Int J Nanomedicine. 2012. Vol. 7. P.1043–1060. 13. Nanodrug delivery in reversing multidrug resistance in cancer cells / S. Kapse-Mistry[etal.] // Front. Pharmacol. 2014. Vol. 5. Р. 159
13. Carbon Nanotubes in Cancer Therapy and Drug Delivery / A. Elhissi [et al.] // Emerging Nanotechnologies in Dentistry. 2012. P.347–363.
14. Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells / R.Li [etal.] // Carbon. 2011. Vol. 49. №5. P.1797–1805.
15. Nanotube molecular transporters: Internalization of carbon nanotube-protein conjugates into mammalian cells / N. W.S. Kam [etal.] // J. Am.Chem. Soc. 2004. Vol. 126. №22. P.6850–6851.
16. Gene delivery nanoparticles to modulate angiogenesis / J. Kim [et al.] // Adv. Drug Deliv. Rev. 2017. Vol.119. P.20–43.
17. K. Wang. Nanoparticles for cancer gene therapy: Recent advances, challenges, and strategies/ K.Wang, F.M. Kievit, M.Zhang// Pharmacol. Res. 2016. Vol. 114. P.56–66.
18. Ovarian cancer treatment with atumor-targeting and gene expression-controllable lipoplex/ Z.Y. He[etal.] // Sci. Rep. 2016. Vol. 6. Р. 23764.
19. First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors / B.Schultheis [etal.] // J.Clin. Oncol. 2014. Vol. 32. №36. P.4141–4148.
Review
For citations:
Stanovaya A., Zhogla V., Galets-Buy I., Loznikova S., Shcherbin D. Nanoparticles in the treatment of malignant neoplasms. Science and Innovations. 2023;1(4):77-83. (In Russ.) https://doi.org/10.29235/1818-9857-2023-04-77-83
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