Generate QR code
Open Access
Subscription Access
Automated bioreactors and dynamic perfusion systems for biomedical research
https://doi.org/10.29235/1818-9857-2026-05-79-83
Abstract
The issue of preclinical testing of medical materials and drugs using automated bioreactors and perfusion dynamic in vitro systems as alternatives to animal models within the 3R principle (Replacement, Reduction, Refinement) is considered. The advantages of such systems are discussed: physiological relevance, control of parameters, reduction of costs and ethical risks. Developments of the Institute of Physiology of the NAS of Belarus are described – bioreactors for modeling antibiotic therapy and testing orthopedic materials.
Keywords
automated bioreactors,
perfusion systems,
preclinical studies,
in vitro models,
antibiotic resistance,
biomaterials
Supporting agencies: The study was financially supported by the Belarusian Republican Foundation for Fundamental Research (grants M23-121, M24U-002)
About the Authors
D. Tapalsky
http://innosfera.by
Institute of Physiology NAS of Belarus
Belarus
Institute of Physiology NAS of Belarus
Belarus
Dmitry Tapalsky, director, Doctor of Medical Sciences, Professor
Minsk
URL: https://innosfera.belnauka.by
M. Simonchik
http://innosfera.by
Institute of Physiology NAS of Belarus
Belarus
Institute of Physiology NAS of Belarus
Belarus
Maria Simonchik, junior research assistant
Center for Medical Microbiology and Antibiotic Resistance
Minsk
URL: https://innosfera.belnauka.by
References
1. Biomaterials Market Size & Share. Industry Report, 2026–2033. Grand View Research, 2026 // https://www.grandviewresearch.com/industry-analysis/biomaterials-industry.
2. Hay M., Thomas D.W., Craigon J.L. [et. al]. Clinical development success rates for investigational drugs // Nature Biotechnology. 2014. №32(1). P. 40–51.
3. Singh N., Vayer P., Tanwar S. Drug discovery and development: introduction to the general public and patient groups // Frontiers in Drug Discovery. 2023. № 3. P. 1201419.
4. Russell W.M.S., Burch R.L. The Principles of Humane Experimental Technique. – London, 1959.
5. Zhu W., Zhang X., Wang D. [et. al]. Simulator of the human intestinal microbial ecosystem (SHIME): current developments, applications, and future prospects // Pharmaceuticals. 2024. № 17. P. 1639.
6. Huh D., Matthews B.D., Mammoto A. [et. al]. Reconstituting organ-level lung functions on a chip // Science. 2010. №328 (5986). P. 1662–1668.
7. Kazimierczak P., Kalisz G., Sroka-Bartnicka A., Przekora A. Effectiveness of the production of tissue-engineered living bone graft: a comparative study using perfusion and rotating bioreactor systems // Scientific Reports. 2023. №13(1). P. 13737.
8. Тапальский Д.В., Колчанова Н.Э. Автоматический проточный биореактор для воспроизведения физиологических условий полости рта in vitro // Новости медико-биологических наук. 2024. № 24 (4). С. 66–72.
Review
For citations:
Tapalsky D., Simonchik M. Automated bioreactors and dynamic perfusion systems for biomedical research. Science and Innovations. 2026;(5):79-83. (In Russ.) https://doi.org/10.29235/1818-9857-2026-05-79-83
Views:
50
JATS XML
Email this article 