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Automated bioreactors and dynamic perfusion systems for biomedical research
https://doi.org/10.29235/1818-9857-2026-05-79-83
Abstract
The issue of preclinical testing of medical materials and drugs using automated bioreactors and perfusion dynamic in vitro systems as alternatives to animal models within the 3R principle (Replacement, Reduction, Refinement) is considered. The advantages of such systems are discussed: physiological relevance, control of parameters, reduction of costs and ethical risks. Developments of the Institute of Physiology of the NAS of Belarus are described – bioreactors for modeling antibiotic therapy and testing orthopedic materials.
Keywords
automated bioreactors,
perfusion systems,
preclinical studies,
in vitro models,
antibiotic resistance,
biomaterials
Supporting agencies: The study was financially supported by the Belarusian Republican Foundation for Fundamental Research (grants M23-121, M24U-002)
About the Authors
D. Tapalsky
http://innosfera.by
Institute of Physiology NAS of Belarus
Belarus
Institute of Physiology NAS of Belarus
Belarus
Dmitry Tapalsky, director, Doctor of Medical Sciences, Professor
Minsk
URL: https://innosfera.belnauka.by
M. Simonchik
http://innosfera.by
Institute of Physiology NAS of Belarus
Belarus
Institute of Physiology NAS of Belarus
Belarus
Maria Simonchik, junior research assistant
Center for Medical Microbiology and Antibiotic Resistance
Minsk
URL: https://innosfera.belnauka.by
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Review
For citations:
Tapalsky D., Simonchik M. Automated bioreactors and dynamic perfusion systems for biomedical research. Science and Innovations. 2026;(5):79-83. (In Russ.) https://doi.org/10.29235/1818-9857-2026-05-79-83
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