|Generate QR code
Open Access
Subscription Access
Targeted drug delivery based on multifunctional dendrimer nanosystems.
https://doi.org/10.29235/1818-9857-2025-5-78-83
Abstract
Targeted delivery of drugs based on dendrimers has a number of advantages for the treatment of cancer. The drug is delivered to specific tissues and organs, thereby minimizing the undesirable effect on healthy cells. Nanoparticles not only reduce the toxicity of anticancer drugs, but also increase their bioavailability and stability in the body. Dendrimers are considered the most promising as drug delivery vehicles due to their non-immunogenicity and controlled synthesis. They have shown their effectiveness in many areas of biology and medicine, namely chemotherapy, vaccine development, and delivery of genetic material. This article provides an overview of multifunctional dendrimer nanosystems that can be used for drug delivery in the treatment and diagnosis of cancer.
Keywords
About the Authors
V. Zhogla
Института биофизики и клеточной инженерии НАН Беларуси
Belarus
Belarus
E. Bletsko
ЦНТ «Евразия»
Russian Federation
Russian Federation
S. Gayibova
Институт биоорганической химии им. академика А.С. Садыкова АН Республики Узбекистан
Uzbekistan
Uzbekistan
V. Shmanai
Институт физико-органической химии НАН Беларуси
Belarus
Belarus
S. Shcharbina
Институт биофизики и клеточной инженерии НАН Беларуси
Belarus
Belarus
References
1. New insights into ruthenium(II) metallodendrimers as anticancer drug nanocarriers: from synthesis to preclinic behavior / D. Maciel [et al.] // J. Mater. Chem. B. 2022. №10. P.8945–8959.
2. Lipid-coated ruthenium dendrimer conjugated with doxorubicin in anti-cancer drug delivery: Introducing protocols / S. Michlewska [et al.] // Colloids Surf. B Biointerfaces. 2023. №227. P.113371. Doi: 10.1016/j.colsurfb.2023.113371.
3. Margetuximab conjugated-PEG-PAMAM G4 nanocomplex: a smart nano-device for suppression of breast cancer / Y. Khakinahad [et al.] // Biomed Eng. Lett. 2022. Apr. 5, №12(3). Р. 317–329. Doi: 10.1007/s13534–022–00225-z.
4. Strengthening Anti-Glioblastoma Effect by Multi-Branched Dendrimers Design of a Scorpion Venom Tetrapeptide / W. Moslah [et al.] // Molecules. 2022. №26, 27(3). Р. 806. Doi: 10.3390/molecules27030806.
5. Linear-Dendritic Polymer-Platinum Complexes Forming Well-Defined Nanocapsules for Acid-Responsive Drug Delivery / K.Liu [et al.] // ACS Appl. Mater. Interfaces. 2021. №13 (37). Р. 44028–44040. Doi: 10.1021/acsami.1c12156.
6. Mechanism of Anticancer Action of Novel Imidazole Platinum(II) Complex Conjugated with G2 PAMAMOH Dendrimer in Breast Cancer Cells / R.Czarnomysy [et al.] // Int. J. Mol. Sci. 2021. May 25, №22 (11). Р. 5581. Doi: 10.3390/ijms22115581.
7. Camacho C. Use of Half-Generation PAMAM Dendrimers (G0.5-G3.5) with Carboxylate End-Groups to Improve the DACHPtCl2 and 5-FU Efficacy as Anticancer Drugs / C. Camacho, H. Tomás, J. Rodrigues // Molecules. 2021. May 14, №26 (10). Р. 2924. Doi: 10.3390/molecules26102924.
8. Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors / W. Jugel [et al.] // Pharmaceutics. 2021. May 8. №13 (5). Р. 676. Doi: 10.3390/pharmaceutics13050676.
9. Polyamidoamine-based nanovector for the efficient delivery of methotrexate to U87 glioma cells / N. Ortiz [et al.] // Nanomedicine (Lond). 2020. Dec, 15, №28. Р. 2771–2784. Doi: 10.2217/nnm2020–0305.
10. Novel design of (PEG-ylated)PAMAM-based nanoparticles for sustained delivery of BDNF to neurotoxin-injured differentiated neuroblastoma cells / M. Dąbkowska [et al.] // J. Nanobiotechnology. 2020. Aug 31, №18 (1). Р. 120. Doi: 10.1186/s12951–020–00673–8.
11. A tumor microenvironment-responsive poly(amidoamine) dendrimer nanoplatform for hypoxia-responsive chemo/chemodynamic therapy / H.Yingchao, [et al.] // J. Nanobiotechnology. 2022. №20. Р. 43.
12. Metal–Phenolic-Network-Coated Dendrimer–Drug Conjugates for Tumor MR Imaging and Chemo/ Chemodynamic Therapy via Amplification of Endoplasmic Reticulum Stress / W.Zhiqiang [et al.] // Adv. Mater. 2022. №34. Р. 2107009.
13. Poly(amidoamine) Dendrimer-Co or dinate d Copper(II) Complexes as a Theranostic Nanoplatform for the Radiotherapy-Enhanced Magnetic Resonance Imaging and Chemotherapy of Tumors and Tumor Metastasis / F.Yu [et al.] // Nano Lett. 2019. №19. Р. 1216–1226.
14. Apoptosis-enhanced ferroptosis therapy of pancreatic carcinoma through PAMAM dendrimeriron(III) complex-based plasmid deliver y / M. Wenjing [et al.] // Sci. China. 2022. Vol. 65, №4. Р. 778–788.
15. Potent Anticancer Efficacy of First-In-Class CuII and AuIII Metaled Phosphorus Dendrons with Distinct Cell Death Pathways / C.Liang [et al.] // Chem. Eur. J. 2020 № 26. Р. 5903–5910.
16. Multifunctional Low-Generation Dendrimer Nanogels as an Emerging Probe for Tumor-Specific CT/MR Dual-Modal Imaging. J. Biol. Macromol. / X.Xu [et al.] // 2023. Feb 13, №24 (2). Р. 967–976. Doi: 10.1021/acs.biomac.2c01403.
17. siAKR1C3@PPA complex nucleic acid nanoparticles inhibit castration-resistant prostate cancer in vitro / X . Cui [et al.] // Fr ont O nco l. 2022. №12. Р. 1069033. Doi: 10.3389/fonc.2022.1069033.
18. Multifunctional nanocarriers for delivering siRNA and siRNA in glioblastoma therapy: advances in nanobiotechnology-based cancer therapy / K. Shetty [et al.] // 3 Biotech. 2022. 12 (11). Р. 301. Doi: 10.1007/s13205–022–03365–2.
19. PAMAM-calix-dendrimers : Synthesis and Thiacalixarene Conformation Effecton DNA Binding / O. Mostovaya [et al.] // Int. J. Mol. Sci. 2021. Vol. 22. P.11901.
20. Non-viral systems based on PAMAM-calixdendrimers for regulatory siRNA delivery into cancer cells / P.Padnya [et al.] // Int. J. Mol. Sci. 2024. №25 (23). Р. 12614. Doi:10.3390/ijms252312614.
21. Characterization of a fluorescent 1,8-naphthalimide-func tionalized PAMAM dendrimer and its Cu(ii) complexes as cytotoxic drugs: EPR and biological studies in myeloid tumor cells / B.Canonico [et al.] // Biol. Chem. 2021. Dec. 10, №403 (3). Р. 345–360. Doi: 10.1515/hsz-2021–0388.
22. Preparing PAMAM-NK4 nano complexes and examining their in vitro growth suppression effects in breast cancer / M.Liu [et al.] // Gland Surg. 2021. №10. Р. 2695–2704. Doi: 10.21037/gs-21–443.
23. Development of 177Lu-DN(C19)-CXCR4 Ligand Nanosystem for Combinatorial Therapy in Pancreatic Cancer / M. Trujillo-Nolasco [et al.] // J. Biomed. Nanotechnol. 2021. №17 (2). Р. 263–278. Doi: 10.1166/jbn.2021.3016.
24. A Radiolabeled Self-assembled Nanoparticle Probe for Diagnosis of Lung-Metastatic Melanoma / T.Tanaka [et al.] // Biol. Pharm. Bull. 2021. №44(3). Р. 410–415. Doi: 10.1248/bpb.b20–00810.
25. Phosphorus dendrimer-based copper(II) complexes enable ultrasound-enhanced tumor theranostics / F.Yu [et al.] // Nano Today. 2020. №33. Р. 100899.
Review
For citations:
Zhogla V., Bletsko E., Gayibova S., Shmanai V., Shcharbina S. Targeted drug delivery based on multifunctional dendrimer nanosystems. Science and Innovations. 2025;1(5):78-83. (In Russ.) https://doi.org/10.29235/1818-9857-2025-5-78-83
Views:
32
Email this article 