A new pathogen Waddlia chondrophila: the relevance of detection and study
https://doi.org/10.29235/1818-9857-2022-3-71-76
Abstract
The problems of diagnosis and significance of the Chlamydia-like bacterium Waddlia chondrophila in the development of human reproductive disorders are highlighted. In-house PCR aimed to detection the 16S rRNA gene fragment of the pathogen was tested. A pilot study was carried out that allowed to detect positive cases in the group of women with miscarriage (2/49, 4.08%). The attention of biomedical specialists is focused on the need for cooperation of efforts in order to develop and implement approaches to the indication and identification of this emerging microorganism, to expand knowledge about its prevalence and etiopathogenetic mechanisms of pathological conditions caused by it.
About the Authors
L. Rubanik
РНПЦ эпидемиологии и микробиологии
Belarus
Belarus
Liudmila Rubanik
N. Poleshchuk
РНПЦ эпидемиологии и микробиологии
Belarus
Belarus
Nikolay Poleshchuk
References
1. Roles of bovine Waddlia chondrophila and Chlamydia trachomatis in human preterm birth / D. Baud [et al.] // New Microbes New Infect. 2015. Vol. 3. P. 41–45.
2. Waddlia chondrophila: from bovine abortion to human miscarriage / D. Baud [et al.] // Clin. Infect. Dis. 2011. Vol. 52. P. 1469–1470.
3. C. J. Lokwood. Predicting premature delivery – no easy task / C. J. Lokwood // N. Engl. J. Med. 2002. Vol. 346. P. 282–284.
4. D. Baud. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes / D. Baud, L. Regan, G. Greub // Curr. Opin. Infect. Dis. 2008. Vol. 21. P. 70–76.
5. G. Goy. Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae / G. Goy, G. Greub // Antimicrob. Agents Chemother. 2009. Vol. 53. P. 2663–2666.
6. Waddlia chondrophila and male infertility / D. Baud [et al.] // Microorganisms. 2020. Vol. 8. P. 136.
7. D. Baud. Intracellular bacteria and adverse pregnancy outcomes / D. Baud, G. Greub // Clin. Microbiol. Infect. 2011. Vol. 17. P. 1312–1322.
8. Identification of immunogenic proteins of Waddlia chondrophila / C. Kebbi- Beghdadi [et al.] // PLoS One. 2012. Vol. 7. e28605.
9. Twenty years of research into Chlamydia-like organisms: a revolution in our understanding of the biology and pathogenicity of members of the phylum Chlamydiae / A. Taylor-Brown [et al.] // Pathog. Dis. 2015. Vol. 73. P. 1–15.
10. Waddlia chondrophila infects and multiplies in ovine trophoblast cells stimulating an inflammatory immune response / N. Wheelhouse [et al.] // PLoSOne. 2014. Vol. 9. e102386.
11. Isolation of a previously undescribed rickettsia from an aborted bovine fetus / P. M. Dilbeck [et al.] // J. Clin. Microbiol. 1990. Vol. 28. P. 814–816.
12. Analysis of the 16S rRNA gene of microorganism WSU86–1044 from an aborted bovine foetus reveals that it is a member of the order Chlamydiales: proposal of Waddliaceae fam. nov., Waddlia chondrophila gen. nov., sp. nov. / F. R. Rurangirwa [et al.] // Int. J. Syst. Bacteriol. 1999. Vol. 49, Pt. 2. P. 577–581.
13. In сontrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the golgi apparatus, or diverting postgolgi sphingomyelin transport / S. Dille[et al.] // Infect. Immun. 2015. Vol. 83, No. 8. P. 3268–3280.
14. The Waddlia genome: a window into chlamydial biology / C. Bertelli [et al.] // PLoSOne. 2010. Vol. 5. e10890.
15. M. M. Fraczek. Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen / M. Fraczek, M. Kurpisz // Folia Histochem.Cytobiol. 2015. Vol. 53, No. 3. P. 201–217.
16. Chlamydia related bacteria (Chlamydiales) in early pregnancy: community-based cohort study/ F. Reid [et al.] // Clin.Microbiol. Infect. 2017. Vol. 23. P. 119.e9–119.e.14.
17. Role of Waddlia chondrophila placental infection in miscarriage / D. Baud [et al.] // Emerg. Infect. Dis. 2014. Vol. 20. P. 460–464.
18. G. Goy. Waddlia chondrophila enters and multiplies within human macrophages / G. Goy, A. Croxatto, G. Greub // Microbes Infect. 2008. Vol. 10. P. 556–562.
19. A. Croxatto. Early intracellular trafficking of Waddlia chondrophila in human macrophages / A. Croxatto, G. Greub // Microbiology. 2010. Vol. 156. P. 340–355.
20. C. Kebbi-Beghdadi. Permissivity of Vero cells, human pneumocytes and human endometrial cells to Waddlia chondrophila / C. Kebbi-Beghdadi, O. Cisse, G. Greub// MicrobesInfect. 2011. Vol. 13. P. 566–574.
21. Prevalence and diversity of Chlamydiales and other amoeba-resisting bacteria in domestic drinking water systems / J. Lienar [et al.] // New Microbes New Infect. 2017. Vol. 15. P. 107–116.
22. Role of Chlamydia trachomatis and emerging Chlamydia-related bacteria in ectopic pregnancy in Vietnam / S. Hornung [et al.] // Epidemiol. Infect. 2015. Vol. 143. P. 2635–2638.
Review
For citations:
Rubanik L., Poleshchuk N. A new pathogen Waddlia chondrophila: the relevance of detection and study. Science and Innovations. 2022;(3):71-76. (In Russ.) https://doi.org/10.29235/1818-9857-2022-3-71-76
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