Interferons and their inducers as elements in control of COVID‑19
Abstract
The article analyzes the properties of various types of interferons, including those recently discovered, discusses the possibility of their use in the treatment of coronavirus, the reasons for the restrictions for some patients, as well as the prospects for the development of a universal antiviral agent by scientists.
About the Authors
A. ZinchenkoBelarus
Anatoly Zinchenko
M. Vinter
Belarus
Margarita Vinter
I. Kazlousk
Belarus
Illia Kazlousk
References
1. A. Isaacs. Virus interference. I. The interferon / A. Isaacs, J. Lindenmann // Proc. R. Soc. Lond. Series B Biol. Sci. 1957. Vol. 147. №927. P. 258–267.
2. L. Ye. Interferon-orchestrate innate and adaptive mucosal immune responses / L. Ye, D. Schnepf, P. Staeheli // Nat. Rev. Immunol. 2019. Vol. 19. P. 614–625.
3. Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells / C. Metz-Zumaran [et al.] // J. Virol. 2022. Vol. 96. №7. Art. e0170521.
4. The effect of recombinant human interferon alpha nasal drops to prevent COVID-19 pneumonia for medical staff in an epidemic area / Z. Meng [et al.] // Curr. Topics Med. Chem. 2021. Vol. 21. №10. P. 920–927.
5. A randomized clinical trial of the efficacy and safety of interferon β-1a in treatment of severe COVID-19 / E. Davoudi-Monfared [et al.] // Antimicrob. Agents Chemother. 2020. Vol. 64. №9. Art. e01061–20.
6. Considering personalized interferon beta therapy for COVID-19 / K. Dorgham [et al.] // Antimicrob. Agents Chemother. 2021. Vol. 65. №4. Art. e00065–21.
7. Л. Л. Рощина. Аптечный ассортимент препаратов группы интерферонов и индукторов интерферонов для профилактики и лечения инфекционных заболеваний / Л. Л. Рощина // Инновации. Наука. Образование. 2021. №29. С. 395–404.
8. А. И. Зинченко. Основы молекулярной биологии вирусов и антивирусной терапии: учеб. пособие / А. И. Зинченко, Д. А. Паруль. – Минск, 2005.
9. Interferon-inducer antivirals: Potential candidates to combat COVID-19 / A. Bagheri [et al.] // Int. Immunopharmacol. 2021. Vol. 91. Art. 107245.
10. G. N. Barber. STING: infection, inflammation and cancer / G. N. Barber // Nat. Rev. Immunol. 2015. Vol. 15, №12. P. 760–770.
11. Exploiting natural antiviral immunity for the control of pandemic s: Les sons f rom Covid-19 / E. Arico [et al.] // Cytokine Growth Factor Rev. 2022. Vol. 63. P. 23–33.
12. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors / L. Deng [et al.] // Immunity. 2014. Vol. 41. №5. P. 843–852.
13. Pharmacological activation of STING blocks SARSCoV-2 infection / M. Li [et al.] // Sci. Immunol. 2021. Vol. 6. Art. eabi9007.
14. Enzymatic synthesis of 2’-ara and 2’-deoxy analogues of c-di-GMP / A. S. Shchokolova [et al.] // Nucleos. Nucleot. Nucl. Acids. 2015. Vol. 34. №6. P. 416–423.
15. М. А. Винтер. Гетерологичная экспрессия диаденилатциклазы в виде телец включения, обладающих ферментативной активностью / М. А. Винтер, И. С. Казловский, А. И. Зинченко // Доклады Национальной академии наук Беларуси. 2022. Т. 66. №5. С. 509–516.
Review
For citations:
Zinchenko A., Vinter M., Kazlousk I. Interferons and their inducers as elements in control of COVID‑19. Science and Innovations. 2023;(2):24-29. (In Russ.)