Proliferative activity of mesenchymal stem cells from different parts of the placenta
https://doi.org/10.29235/1818-9857-2021-7-76-80
Abstract
The ability of mesenchymal stem cells (MSCs) isolated from the decidua, chorionic tissue and amniotic membrane of the placenta to the self-renewal and the proliferation was investigated. Our results revealed that the number of colony forming unit-fibroblast (CFU-F) and the growth rate of MSCs were higher in the decidua and chorionic tissue compared to the amniotic membrane. Decidua MSCs and chorionic MSCs possessed a similar powerful proliferative potential and increased in 1010- fold in cultures for 3 months, that is 103 times more then the amniotic MSCs. The cumulative population doubling (PD) of placenta-derived MSCs was significantly higher at all passages then PD of bone marrow derived MSCs. The decidua and chorionic tissue of the placenta are ideal MSCs sources for cell based therapy.
About the Authors
Y. Isaykina
РНПЦ детской онкологии, гематологии и иммунологии
Belarus
Belarus
E. Lyakh
РНПЦ детской онкологии, гематологии и иммунологии
Belarus
Belarus
M. Novikova
РНПЦ детской онкологии, гематологии и иммунологии
Belarus
Belarus
Y. Savich
РНПЦ детской онкологии, гематологии и иммунологии
Belarus
Belarus
L. Keda
Главное управление организации медицинской
помощи Министерства здравоохранения Республики Беларусь
Belarus
Belarus
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Review
For citations:
Isaykina Y., Lyakh E., Novikova M., Savich Y., Keda L. Proliferative activity of mesenchymal stem cells from different parts of the placenta. Science and Innovations. 2021;(7):76-80. (In Russ.) https://doi.org/10.29235/1818-9857-2021-7-76-80
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