innosferaНаука и инновацииScience and Innovations1818-98572412-9372Издательский дом «Белорусская наука»10.29235/1818-9857-2025-5-78-83innosfera-829Research ArticleДИССЕРТАЦИОННЫЕ ИССЛЕДОВАНИЯDISSERTATION RESEARCHТаргетная доставка лекарств на основе мультифункциональных дендримерных наносистемTargeted drug delivery based on multifunctional dendrimer nanosystems.ЖоглаВ.ZhoglaV.

Виктория Жогла, научный сотрудник лаборатории нанобиотехнологий Института биофизики и клеточной инженерии НАН Беларуси, аспирант

victoriya.zhogla@gmail.comБлетькоЕ.BletskoE.

Елизавета Блетько, специалист по организации токсикологических испытаний медицинских изделий ЦНТ «Евразия»Москва

ГайибоваС.GayibovaS.

Сабина Гайибова, старший научный сотрудник лаборатории растительных цитопротекторов Института биоорганической химии им. академика А.С. Садыкова АН Республики Узбекистан, кандидат биологических наук

ШманайВ.ShmanaiV.

Вадим Шманай, заведующий лабораторией химии биоконъюгатов Института физико-органической химии НАН Беларуси, кандидат химических наук 

ЩербинаН.ShcharbinaS.

Наталья Щербина, врач лабораторной диагностики клеточного центра Института биофизики и клеточной инженерии НАН Беларуси, кандидат биологическихнаук

Института биофизики и клеточной инженерии НАН БеларусиBelarusЦНТ «Евразия»Russian FederationИнститут биоорганической химии им. академика А.С. Садыкова АН Республики УзбекистанUzbekistanИнститут физико-органической химии НАН БеларусиBelarusИнститут биофизики и клеточной инженерии НАН БеларусиBelarus202521062025157883Copyright © Издательский дом «Белорусская наука», 20252025Издательский дом «Белорусская наука»Издательский дом «Белорусская наука»https://innosfera.belnauka.by/jour/about/submissions#copyrightNoticehttps://innosfera.belnauka.by/jour/article/view/829

Таргетная доставка лекарственных веществ на основе дендримеров имеет ряд преимуществ при лечении онкологических заболеваний, так как осуществляется в конкретные ткани и органы, благодаря чему нежелательное влияние на здоровые клетки сводится к минимуму. Наночастицы не только снижают токсичность противоопухолевых препаратов, но и повышают их биодоступность и устойчивость в среде организма. Дендримеры ввиду их неиммуногенности и контролируемого синтеза считаются наиболее перспективными среди средств доставки лекарств, они продемонстрировали свою эффективность во многих областях биологии и медицины –  в химиотерапии, разработке вакцин, доставке генетического материала. В данной статье приведен обзор мультифункциональных наносистем на их основе. 

Targeted delivery of drugs based on dendrimers has a number of advantages for the treatment of cancer. The drug is delivered to specific tissues and organs, thereby minimizing the undesirable effect on healthy cells. Nanoparticles not only reduce the toxicity of anticancer drugs, but also increase their bioavailability and stability in the body. Dendrimers are considered the most promising as drug delivery vehicles due to their non-immunogenicity and controlled synthesis. They have shown their effectiveness in many areas of biology and medicine, namely chemotherapy, vaccine development, and delivery of genetic material. This article provides an overview of multifunctional dendrimer nanosystems that can be used for drug delivery in the treatment and diagnosis of cancer. 

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The authors declare that there are no conflicts of interest present.