innosferaНаука и инновацииScience and Innovations1818-98572412-9372Издательский дом «Белорусская наука»10.29235/1818-9857-2025-01-78-83innosfera-746Research ArticleДИССЕРТАЦИОННЫЕ ИССЛЕДОВАНИЯDISSERTATION RESEARCHДендримерные многофункциональные комплексы для генетической терапии ракаDendrimer multifunctional complexes for genetic therapy of cancerСтановаяА.StanovayaAlesia

Алеся  Становая, научный сотрудник лаборатории нанобиотехнологий, аспирант

alesiastanovaya@gmail.comТереховаМ.TerekhovaMaria

Мария Терехова, научный сотрудник лаборатории нанобиотехнологий 

maryja.cierachava@yandex.byАбашкинВ.AbashkinViktar

Виктор  Абашкин, завлабораторией нанобиотехнологий, кандидат биологических наук

УлащикЕ.UlashchikEgor

Егор Улащик, научный сотрудник лаборатории химии биоконъюгатов 

ЩербинД.ShcherbinDzmitry

Дмитрий Щербин, завотделом медицинских биотехнологий, доктор биологических наук, профессор

Институт биофизики и клеточной инженерии НАН БеларусиBelarusИнститут физико-органической химии НАН БеларусиBelarus202518022025117883Copyright © Издательский дом «Белорусская наука», 20252025Издательский дом «Белорусская наука»Издательский дом «Белорусская наука»https://innosfera.belnauka.by/jour/about/submissions#copyrightNoticehttps://innosfera.belnauka.by/jour/article/view/746

В статье представлен обзор синтезированных к настоящему времени наночастиц, перспективных для применения в терапии онкозаболеваний в качестве носителей лекарств и нуклеиновых кислот, а также для снижения токсичности противоопухолевых препаратов. Затрагиваются вопросы взаимодействия различных наноматериалов с малыми противораковыми РНК. Приведены данные использования некоторых нетоксичных и эффективных многофункциональных наноконъюгатов в генной терапии для лечения и диагностики онкологических заболеваний.

Every year there is a rapid increase in cancer, which is one of the main causes of death. Methods used to treat cancer often do not produce the desired results and can cause various side effects. Therefore, to effectively combat cancer, it is necessary to find new solutions. The use of nanotechnology opens up new opportunities in the diagnosis and treatment of human malignant tumors. Nanoparticles used in antitumor therapy can act as carriers of drugs and nucleic acids,  and also reduce the toxicity of anticancer drugs. This review is devoted to the analysis of the interaction of various nanomaterials with small anticancer RNAs.  Data are presented on the use of some non-toxic and effective multifunctional nanoconjugates in gene therapy for the treatment and diagnosis of cancer.

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The authors declare that there are no conflicts of interest present.