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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">innosfera</journal-id><journal-title-group><journal-title xml:lang="ru">Наука и инновации</journal-title><trans-title-group xml:lang="en"><trans-title>Science and Innovations</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-9857</issn><issn pub-type="epub">2412-9372</issn><publisher><publisher-name>Издательский дом «Белорусская наука»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29235/1818-9857-2023-11-27-31</article-id><article-id custom-type="elpub" pub-id-type="custom">innosfera-514</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТЕМА НОМЕРА: ЭМЕРДЖЕНТНОСТЬ: КОНТЕКСТ ИМЕЕТ ЗНАЧЕНИЕ</subject></subj-group></article-categories><title-group><article-title>Трехмерное культивирование клеток и биопринтинг</article-title><trans-title-group xml:lang="en"><trans-title>Three-dimensional cell cultivation and bioprinting</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисов</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisov</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрей Денисов, заведующий лабораторией клеточной инженерии и нанобиотехнологий кафедры биофизики физического факультета Белорусского государственного университета, ведущий научный сотрудник лаборатории нейрофизиологии Института физиологии НАН Беларуси, кандидат биологических наук</p></bio><bio xml:lang="en"><p>Andrey Denisov</p></bio><email xlink:type="simple">an.denisov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пашкевич</surname><given-names>С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pashkevich</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана Пашкевич, заведующий лабораторией нейрофизиологии, кандидат биологических наук, доцент</p></bio><bio xml:lang="en"><p>Svetlana Pashkevich</p></bio><email xlink:type="simple">skypasht@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Белорусский государственный университет; Институт физиологии НАН Беларуси</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт физиологии НАН Беларуси</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>08</day><month>12</month><year>2023</year></pub-date><volume>0</volume><issue>11</issue><fpage>27</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Издательский дом «Белорусская наука», 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Издательский дом «Белорусская наука»</copyright-holder><copyright-holder xml:lang="en">Издательский дом «Белорусская наука»</copyright-holder><license xlink:href="https://innosfera.belnauka.by/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://innosfera.belnauka.by/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://innosfera.belnauka.by/jour/article/view/514">https://innosfera.belnauka.by/jour/article/view/514</self-uri><abstract><p>Представлены подходы к формированию плоских и объемных клеточных паттернов с применением метода биопринтинга, обсуждаются особенности трехмерного культивирования, когда за счет более интенсивных межклеточных взаимодействий у клеточного ансамбля появляются свойства, нехарактерные для одиночных клеток, создаются условия, необходимые для возникновения процессов самоорганизации в системе взаимодействующих клеток, трансформации в тканеподобные и органоподобные структуры. Современные методы биопринтинга позволяют увеличить производительность этих процессов путем инженерного внесения дополнительных уровней организации.</p></abstract><trans-abstract xml:lang="en"><p>The paper presents approaches to the formation of ﬂat and three-dimensional cellular patterns using bioprinting methods, discusses the features of three-dimensional culture, when due to more intensive intercellular interactions the cell ensemble has properties that are not typical for single cells, the conditions necessary for the emergence of self-organization processes are created in the system of interacting cells, transformation into tissue-like and organ-like structures. Modern bioprinting methods provide increased productivity of these processes by engineering the additional levels of organization.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>трехмерное клеточное культивирование</kwd><kwd>гидрогели</kwd><kwd>биопринтинг</kwd></kwd-group><kwd-group xml:lang="en"><kwd>three-dimensional cell culture</kwd><kwd>hydrogels</kwd><kwd>bioprinting</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">D. Sun [et al.]. Why 90% of clinical drug development fails and how to improve it? // Acta Pharm Sin B. 2022. Vol. 12. №7. P. 3049–3062.</mixed-citation><mixed-citation xml:lang="en">D. Sun [et al.]. Why 90% of clinical drug development fails and how to improve it? // Acta Pharm Sin B. 2022. Vol. 12. №7. P. 3049–3062.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">A.B. 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