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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">innosfera</journal-id><journal-title-group><journal-title xml:lang="ru">Наука и инновации</journal-title><trans-title-group xml:lang="en"><trans-title>Science and Innovations</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-9857</issn><issn pub-type="epub">2412-9372</issn><publisher><publisher-name>Издательский дом «Белорусская наука»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29235/1818-9857-2022-2-24-35</article-id><article-id custom-type="elpub" pub-id-type="custom">innosfera-35</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОМЕДИЦИНСКИЕ АСПЕКТЫ ИММУНОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>Новые биомедицинские клеточные продукты для иммунотерапии заболеваний человека</article-title><trans-title-group xml:lang="en"><trans-title>Characteristics of the immunity system in patients with pneumonia associated with COVID‑19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бобрукевич</surname><given-names>Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Bobrukevich</surname><given-names>D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дарья Бобрукевич, младший научный сотрудник лаборатории иммунологии и клеточной биофизики</p></bio><bio xml:lang="en"><p>Daria Bobrukevich</p></bio><email xlink:type="simple">bobrukevich.darya@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антоневич</surname><given-names>Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Antonevich</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Антоневич, завлабораторией иммунологии и клеточной биофизики, кандидат биологических наук</p></bio><bio xml:lang="en"><p>Natalya Antonevich  </p></bio><email xlink:type="simple">antonevich.n@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончаров</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Hancharou</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрей Гончаров, директор, кандидат медицинских наук, доцент</p></bio><bio xml:lang="en"><p>Andrei Hancharou</p></bio><email xlink:type="simple">andrei.hancharou@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рында</surname><given-names>Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Rynda</surname><given-names>E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Рында, научный сотрудник лаборатории иммунологии и клеточной биофизики</p></bio><bio xml:lang="en"><p>Elena Rynda</p></bio><email xlink:type="simple">alenarynda@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимохина</surname><given-names>О.</given-names></name><name name-style="western" xml:lang="en"><surname>Timokhina</surname><given-names>O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оксана Тимохина, научный сотрудник лаборатории иммунологии и клеточной биофизики</p></bio><bio xml:lang="en"><p>Oksana Timokhina</p></bio><email xlink:type="simple">oksanabuschik@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Минич</surname><given-names>Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Minich</surname><given-names>Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Яна Минич, младший научный сотрудник лаборатории иммунологии и клеточной биофизики</p></bio><bio xml:lang="en"><p>Yana Minich</p></bio><email xlink:type="simple">yana-minich@tut.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Головач</surname><given-names>Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Golovach</surname><given-names>E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Головач, младший научный сотрудник лаборатории иммунологии и клеточной биофизики</p></bio><bio xml:lang="en"><p>Elena Golovach</p></bio><email xlink:type="simple">elenabriche@mail.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доценко</surname><given-names>М.</given-names></name><name name-style="western" xml:lang="en"><surname>Dotsenko</surname><given-names>M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марина Доценко, заместитель заведующего кафедрой инфекционных болезней, доктор медицинских наук, профессор</p></bio><bio xml:lang="en"><p>Marina Dotsenko</p></bio><email xlink:type="simple">mar_dots@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доценко</surname><given-names>Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Dotsenko</surname><given-names>E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эдуард Доценко, заведующий кафедрой пропедевтики внутренних болезней, доктор медицинских наук</p></bio><bio xml:lang="en"><p>Eduard Dotsenko</p></bio><email xlink:type="simple">ed_dots@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Институт биофизики и клеточной инженерии НАН Беларуси</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Белорусский государственный медицинский университет</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>2</issue><fpage>24</fpage><lpage>35</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Издательский дом «Белорусская наука», 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Издательский дом «Белорусская наука»</copyright-holder><copyright-holder xml:lang="en">Издательский дом «Белорусская наука»</copyright-holder><license xlink:href="https://innosfera.belnauka.by/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://innosfera.belnauka.by/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://innosfera.belnauka.by/jour/article/view/35">https://innosfera.belnauka.by/jour/article/view/35</self-uri><abstract><p>Проведен расширенный анализ иммунных параметров, характеризующих дифференцировку, активацию и истощение лимфоцитов, моноцитов и гранулоцитов у пациентов со среднетяжелой и тяжелой пневмонией COVID-19.</p></abstract><trans-abstract xml:lang="en"><p>The advanced analysis of immune parameters describing diﬀerentiation proﬁle, activation and exhaustion of lymphocytes, monocytes and granulocytes of patients with moderate and severe/critical COVID‑19 pneumonia was performed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>иммунитет</kwd><kwd>пневмония</kwd><kwd>иммунные параметры</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID‑19</kwd><kwd>SARS‑CoV‑2</kwd><kwd>immu‑ nity</kwd><kwd>pneumonia</kwd><kwd>immune parameters</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sustained cellular immune dysregulation in individuals recovering from SARS CoV 2 infection / Files J. 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