<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">innosfera</journal-id><journal-title-group><journal-title xml:lang="ru">Наука и инновации</journal-title><trans-title-group xml:lang="en"><trans-title>Science and Innovations</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-9857</issn><issn pub-type="epub">2412-9372</issn><publisher><publisher-name>Издательский дом «Белорусская наука»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">innosfera-1103</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СОВРЕМЕННЫЕ АСПЕКТЫ АЛЛЕРГОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>Провокационное аллерготестирование гиперчувствительности к металлам</article-title><trans-title-group xml:lang="en"><trans-title>Provocative allergy testing for metal hypersensitivity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аляхнович</surname><given-names>Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Alyakhnovich</surname><given-names>Natalia</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Аляхнович, доцент кафедры клинической иммунологии и аллергологии с курсом ФПК и ПК, кандидат медицинских наук, доцент </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ищенко</surname><given-names>О.</given-names></name><name name-style="western" xml:lang="en"><surname>Ishchenko</surname><given-names>Oksana</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оксана Ищенко, заведующий кафедрой клинической иммунологии и аллергологии с курсом ФПК и ПК, доктор медицинских наук, профессор </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Витебский государственный медицинский университет</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>13</day><month>10</month><year>2026</year></pub-date><volume>0</volume><issue>9</issue><fpage>16</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аляхнович Н., Ищенко О., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Аляхнович Н., Ищенко О.</copyright-holder><copyright-holder xml:lang="en">Alyakhnovich N., Ishchenko O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://innosfera.belnauka.by/jour/article/view/1103">https://innosfera.belnauka.by/jour/article/view/1103</self-uri><abstract><p>Описаны методы провокационного аллерготестирования, позволяющие выявить сенсибилизацию к металлам у пациентов с симптомами непереносимости металлоконструкций. </p></abstract><trans-abstract xml:lang="en"><p> The article describes provocative allergy testing methods that can help detect metal sensitization in patients with symptoms of metal intolerance. </p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Metal Hypersensitivity and Contact Dermatitis in Orthopedic Hardware and Biocompatible Implants / А. Cevetello [et al.] // Dermis. 2025. №5(3). P. 37.</mixed-citation><mixed-citation xml:lang="en">Metal Hypersensitivity and Contact Dermatitis in Orthopedic Hardware and Biocompatible Implants / А. Cevetello [et al.] // Dermis. 2025. №5(3). P. 37.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Marwa K. Type IV Hypersensitivity Reaction / K. Marwa, N.P. Kondamudi // https://www.ncbi.nlm.nih.gov/books/NBK562228.</mixed-citation><mixed-citation xml:lang="en">Marwa K. Type IV Hypersensitivity Reaction / K. Marwa, N.P. Kondamudi // https://www.ncbi.nlm.nih.gov/books/NBK562228.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Badell J.S. Metal allergy and the use of custom implants in primary total ankle replacement / J.S. Badell, J.M. Cottom // Foot &amp; Ankle Surgery: Techniques, Reports &amp; Cases. 2023. №3(2). P. 100285.</mixed-citation><mixed-citation xml:lang="en">Badell J.S. Metal allergy and the use of custom implants in primary total ankle replacement / J.S. Badell, J.M. Cottom // Foot &amp; Ankle Surgery: Techniques, Reports &amp; Cases. 2023. №3(2). P. 100285.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Pacheco K.A. Contact Dermatitis From Biomedical Devices, Implants, and Metals-Trouble From Within / K.A. Pacheco, J.P. Thyssen // The Journal of Allergy and Clinical Immunology. 2024. №12(9). P. 2280–2295.</mixed-citation><mixed-citation xml:lang="en">Pacheco K.A. Contact Dermatitis From Biomedical Devices, Implants, and Metals-Trouble From Within / K.A. Pacheco, J.P. Thyssen // The Journal of Allergy and Clinical Immunology. 2024. №12(9). P. 2280–2295.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Tapscott D.C Or thopedic Implant Materials / D.C. Tapscott, C. Wottowa // https://www.ncbi.nlm.nih.gov/books/NBK560505.</mixed-citation><mixed-citation xml:lang="en">Tapscott D.C Or thopedic Implant Materials / D.C. Tapscott, C. Wottowa // https://www.ncbi.nlm.nih.gov/books/NBK560505.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Biomedical titanium alloys with Young’s moduli close to that of cortical bone / M. Niinomi [et al.] // Regen Biomater. 2016. №3(3). P. 173–185.</mixed-citation><mixed-citation xml:lang="en">Biomedical titanium alloys with Young’s moduli close to that of cortical bone / M. Niinomi [et al.] // Regen Biomater. 2016. №3(3). P. 173–185.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C. The contribution of metal allergy to the failure of metal alloy implants, with special reference to titanium: Current knowledge and controversies / C. Huang, S.Y.V. Chiang, D.J. Gawkrodger // Contact Dermatitis. 2024. №90 (3). P. 201–210. Doi: 10.1111/cod.14481.</mixed-citation><mixed-citation xml:lang="en">Huang C. The contribution of metal allergy to the failure of metal alloy implants, with special reference to titanium: Current knowledge and controversies / C. Huang, S.Y.V. Chiang, D.J. Gawkrodger // Contact Dermatitis. 2024. №90 (3). P. 201–210. Doi: 10.1111/cod.14481.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Merwe J.M. Metal Hypersensitivity in Joint Arthroplasty / J.M. Van der Merwe // Journal of the American Academy of Orthopaedic Surgeons: Global Research &amp; Reviews. 2021. №5 (3). P. e20.00200.</mixed-citation><mixed-citation xml:lang="en">Van der Merwe J.M. Metal Hypersensitivity in Joint Arthroplasty / J.M. Van der Merwe // Journal of the American Academy of Orthopaedic Surgeons: Global Research &amp; Reviews. 2021. №5 (3). P. e20.00200.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Richards L.J. Utility of Patch Testing and Lymphocyte Transformation Testing in the Evaluation of Metal Allergy in Patients with Orthopedic Implants / L.J. Richards, A. Streifel, J.M.Rodrigues // Cureus. 2019. №11 (9). P. e5761.</mixed-citation><mixed-citation xml:lang="en">Richards L.J. Utility of Patch Testing and Lymphocyte Transformation Testing in the Evaluation of Metal Allergy in Patients with Orthopedic Implants / L.J. Richards, A. Streifel, J.M.Rodrigues // Cureus. 2019. №11 (9). P. e5761.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Poor Correlation Among Metal Hypersensitivity Testing Modalities and Inferior Patient-Reported Outcomes After Primary and Revision Total Knee Arthroplasties / D.N. Bracey [et al.] // Arthroplast Today. 2022. №18. P. 138–142.</mixed-citation><mixed-citation xml:lang="en">Poor Correlation Among Metal Hypersensitivity Testing Modalities and Inferior Patient-Reported Outcomes After Primary and Revision Total Knee Arthroplasties / D.N. Bracey [et al.] // Arthroplast Today. 2022. №18. P. 138–142.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Alontseva D. Biocompatibility and Corrosion of Microplasma-Sprayed Titanium and Tantalum Coatings versus Titanium Alloy / D. Alontseva [et al.] // Coatings. 2024. №14 (2). P. 206.</mixed-citation><mixed-citation xml:lang="en">Alontseva D. Biocompatibility and Corrosion of Microplasma-Sprayed Titanium and Tantalum Coatings versus Titanium Alloy / D. Alontseva [et al.] // Coatings. 2024. №14 (2). P. 206.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Аляхнович Н.С. Валидация опросника по выявлению риска гиперчувствительности к титану и его оксиду / Н.С. Аляхнович, Ихсас А. Мохамед // Иммунопатология, аллергология, инфектология. 2024. №(4). Р. 99–105. DOI: 10.18621/iah.2024.4.11. EDN: QLXTNZ.</mixed-citation><mixed-citation xml:lang="en">Аляхнович Н.С. Валидация опросника по выявлению риска гиперчувствительности к титану и его оксиду / Н.С. Аляхнович, Ихсас А. Мохамед // Иммунопатология, аллергология, инфектология. 2024. №(4). Р. 99–105. DOI: 10.18621/iah.2024.4.11. EDN: QLXTNZ.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Аляхнович Н.С. Кожное аппликационное тестирование как инструмент диагностики аллергического контактного дерматита на металлы / Н.С. Аляхнович // Иммунопатология, аллергология, инфектология. 2026. №2. Р. 15–22.</mixed-citation><mixed-citation xml:lang="en">Аляхнович Н.С. Кожное аппликационное тестирование как инструмент диагностики аллергического контактного дерматита на металлы / Н.С. Аляхнович // Иммунопатология, аллергология, инфектология. 2026. №2. Р. 15–22.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Аллергия к титану – от анамнеза до постановки диагноза / Н.С. Аляхнович [и др.] // Медицинские новости. 2026. №1. Р. 55–59.</mixed-citation><mixed-citation xml:lang="en">Аллергия к титану – от анамнеза до постановки диагноза / Н.С. Аляхнович [и др.] // Медицинские новости. 2026. №1. Р. 55–59.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Аляхнович Н.С. Клиника и диагностика гиперчувствительности, вызванной титаном и его оксидом / Н.С. Аляхнович // Рецепт. 2022. №25 (6). С. 771–780</mixed-citation><mixed-citation xml:lang="en">Аляхнович Н.С. Клиника и диагностика гиперчувствительности, вызванной титаном и его оксидом / Н.С. Аляхнович // Рецепт. 2022. №25 (6). С. 771–780</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
