<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">innosfera</journal-id><journal-title-group><journal-title xml:lang="ru">Наука и инновации</journal-title><trans-title-group xml:lang="en"><trans-title>Science and Innovations</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-9857</issn><issn pub-type="epub">2412-9372</issn><publisher><publisher-name>Издательский дом «Белорусская наука»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">innosfera-1060</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТЕМА НОМЕРА: ТЕХНОЛОГИИ СУВЕРЕНИТЕТА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ТЕМА НОМЕРА: ТЕХНОЛОГИИ СУВЕРЕНИТЕТА</subject></subj-group></article-categories><title-group><article-title>CAR-T-терапия: сегодня и завтра</article-title><trans-title-group xml:lang="en"><trans-title>CAR-T therapy: today and tomorrow</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дорошенко</surname><given-names>Татьяна</given-names></name><name name-style="western" xml:lang="en"><surname>Doroshenko</surname><given-names>Tatyana</given-names></name></name-alternatives><bio xml:lang="ru"><p>Татьяна Дорошенко, заведующий отделением клеточных технологий Республиканской молекулярно-генетической лаборатории канцерогенеза, кандидат биологических наук, доцент,</p><p>Минск.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дормешкин</surname><given-names>Дмитрий</given-names></name><name name-style="western" xml:lang="en"><surname>Dormeshkin</surname><given-names>Dmitry</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитрий Дормешкин, ведущий научный сотрудник лаборатории молекулярной диагностики биотехнологий, кандидат химических наук, доцент,</p><p>Минск.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красный</surname><given-names>Сергей</given-names></name><name name-style="western" xml:lang="en"><surname>Krasny</surname><given-names>Sergey</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергей Красный, заместитель директора по научной работе, доктор медицинских наук, академик,</p><p>Минск.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>РНПЦ онкологии и медицинской радиологии им. Н.Н. Александрова</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт биоорганической химии НАН Беларуси</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>21</day><month>07</month><year>2026</year></pub-date><volume>0</volume><issue>6</issue><fpage>28</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Издательский дом «Белорусская наука», 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Издательский дом «Белорусская наука»</copyright-holder><copyright-holder xml:lang="en">Издательский дом «Белорусская наука»</copyright-holder><license xlink:href="https://innosfera.belnauka.by/jour/about/submissions#copyrightNotice" xlink:type="simple"><license-p>https://innosfera.belnauka.by/jour/about/submissions#copyrightNotice</license-p></license></permissions><self-uri xlink:href="https://innosfera.belnauka.by/jour/article/view/1060">https://innosfera.belnauka.by/jour/article/view/1060</self-uri><abstract><p>Показаны возможности CAR T-терапии – генно-инженерного клеточного метода, который стал прорывом в лечении онкологических заболеваний, а также достижения белорусских ученых в этой передовой области.</p></abstract><trans-abstract xml:lang="en"><p>The article analyzes the potential of CAR-T therapy – a genetically engineered cell method that has become a breakthrough in cancer treatment, and highlights the achievements of Belarusian scientists in this cutting-edge field.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">CAR-T cell therapy for cancer: current challenges and future directions / I. Zugasti, L. Espinosa-Aroca, K. Fidyt // Signal Transduct Target Ther. 2025. Jul №4 10(1) Р. 210. https://doi.org/10.1038/s41392-025-02269-w/.</mixed-citation><mixed-citation xml:lang="en">CAR-T cell therapy for cancer: current challenges and future directions / I. Zugasti, L. Espinosa-Aroca, K. Fidyt // Signal Transduct Target Ther. 2025. Jul №4 10(1) Р. 210. https://doi.org/10.1038/s41392-025-02269-w/.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived c regions / Y. Kuwana, Y. Asakura, N. Utsunomiya [et al.] // Biochem Biophys Res C o m m u n . 19 87. №149. Р. 9 6 0 – 9 6 8 . https://doi.org/10.1016/0006-291X(87)90502-X.</mixed-citation><mixed-citation xml:lang="en">Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived c regions / Y. Kuwana, Y. Asakura, N. Utsunomiya [et al.] // Biochem Biophys Res C o m m u n . 19 87. №149. Р. 9 6 0 – 9 6 8 . https://doi.org/10.1016/0006-291X(87)90502-X.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gross G. Expression of immunoglobulin-t-cell receptor chimeric molecules as functional receptors with antibody-type specificity / G. Gross, T. Waks, Z. Eshhar // Proc Natl Acad Sci U.S.A. 1989. №86. Р. 10024–10028. https://doi.org/10.1073/pnas.86.24.10024.</mixed-citation><mixed-citation xml:lang="en">Gross G. Expression of immunoglobulin-t-cell receptor chimeric molecules as functional receptors with antibody-type specificity / G. Gross, T. Waks, Z. Eshhar // Proc Natl Acad Sci U.S.A. 1989. №86. Р. 10024–10028. https://doi.org/10.1073/pnas.86.24.10024.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">From bench to bedside: the history and progress of CAR T cell therapy / A. Mitra, A. Barua, L. Huang [et al.] // Front Immunol. 2023. №15. Р. 1188049. https://doi.org/10.3389/fimmu.2023.1188049.</mixed-citation><mixed-citation xml:lang="en">From bench to bedside: the history and progress of CAR T cell therapy / A. Mitra, A. Barua, L. Huang [et al.] // Front Immunol. 2023. №15. Р. 1188049. https://doi.org/10.3389/fimmu.2023.1188049.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">T Current updates on generations, approvals, and clinical trials of CAR T-cell therapy / Asmamaw Dejenie, G. Tiruneh M. Medhin [et al.] // Hum Vaccin Immunother. 2022. №18(6). Р. 2114254. https://doi.org/10.1080/21645515.2022.2114254.</mixed-citation><mixed-citation xml:lang="en">T Current updates on generations, approvals, and clinical trials of CAR T-cell therapy / Asmamaw Dejenie, G. Tiruneh M. Medhin [et al.] // Hum Vaccin Immunother. 2022. №18(6). Р. 2114254. https://doi.org/10.1080/21645515.2022.2114254.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">CAR-T cell manufacturing: Major process parameters and next-generation strategies / M. Ayala Ceja, M. Khericha, C. M. Harris [et al.] // J Exp Med. 2024. №221(2). Р. e20230903. https://doi.org/10.1084/jem.20230903.</mixed-citation><mixed-citation xml:lang="en">CAR-T cell manufacturing: Major process parameters and next-generation strategies / M. Ayala Ceja, M. Khericha, C. M. Harris [et al.] // J Exp Med. 2024. №221(2). Р. e20230903. https://doi.org/10.1084/jem.20230903.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sterner R.C. CAR-T cell therapy: current limitations and potential strategies / R. C Sterner, R. M. Sterner // Blood Cancer J. 2021. №11(4). Р. 69. https://doi.org/10.1038/s41408-021-00459-7.</mixed-citation><mixed-citation xml:lang="en">Sterner R.C. CAR-T cell therapy: current limitations and potential strategies / R. C Sterner, R. M. Sterner // Blood Cancer J. 2021. №11(4). Р. 69. https://doi.org/10.1038/s41408-021-00459-7.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Alsaieedi A.A. Tracing the development of CAR-T cell design: from concept to next-generation platforms / A.A. Alsaieedi, K.A. Zaher // Front. Immunol. 2025. №16. Р. 1615212. https://doi.org/10.3389/fimmu.2025.1615212.</mixed-citation><mixed-citation xml:lang="en">Alsaieedi A.A. Tracing the development of CAR-T cell design: from concept to next-generation platforms / A.A. Alsaieedi, K.A. Zaher // Front. Immunol. 2025. №16. Р. 1615212. https://doi.org/10.3389/fimmu.2025.1615212.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">The European CAR-T map-Current status and future directions to improve access to CAR T-cell therapy for hematologic malignancies / E.R. Pennings, F.W. Thielen, F. Broussais [et al.] // Hemasphere. 2026. №10(3). Р. e70306. https://doi.org/10.1002/hem3.70306.</mixed-citation><mixed-citation xml:lang="en">The European CAR-T map-Current status and future directions to improve access to CAR T-cell therapy for hematologic malignancies / E.R. Pennings, F.W. Thielen, F. Broussais [et al.] // Hemasphere. 2026. №10(3). Р. e70306. https://doi.org/10.1002/hem3.70306.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hill J.A. CAR-T – and a side order of IgG, to go? Immunoglobulin replacement in patients receiving CAR-T cell therapy / J.A. Hill, S. Giralt, T.R. Torgerson, H.M. Lazarus // Blood Rev. 2019. №38. Р. 100596. https://doi.org/10.1016/j.blre.2019.100596.</mixed-citation><mixed-citation xml:lang="en">Hill J.A. CAR-T – and a side order of IgG, to go? Immunoglobulin replacement in patients receiving CAR-T cell therapy / J.A. Hill, S. Giralt, T.R. Torgerson, H.M. Lazarus // Blood Rev. 2019. №38. Р. 100596. https://doi.org/10.1016/j.blre.2019.100596.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Comparative real-world outcomes of CD19-directed CAR T-cell therapies in large B-cell lymphoma / X. Deschênes-Simard, M. Bromberg, S.M. Devlin [et al.] // Blood Adv. 2025. №9 (21). Р. 5571–5584.</mixed-citation><mixed-citation xml:lang="en">Comparative real-world outcomes of CD19-directed CAR T-cell therapies in large B-cell lymphoma / X. Deschênes-Simard, M. Bromberg, S.M. Devlin [et al.] // Blood Adv. 2025. №9 (21). Р. 5571–5584.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies / Y. Zhao, D. Zhang, Y. Guo [et al.] // Front. Oncol. 2021. №11. Р. 680834. https://doi.org/10.3389/fonc.2021.680834.</mixed-citation><mixed-citation xml:lang="en">Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies / Y. Zhao, D. Zhang, Y. Guo [et al.] // Front. Oncol. 2021. №11. Р. 680834. https://doi.org/10.3389/fonc.2021.680834.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rebagay G. ROR1 and ROR2 in Human Malignancies: Potentials for Targeted Therapy / G. Rebagay, S. Yan, C. Liu and N.K. Cheung // Front. Oncol. 2012. №2. Р. 34. https://doi.org/10.3389/fonc.2012.00034.</mixed-citation><mixed-citation xml:lang="en">Rebagay G. ROR1 and ROR2 in Human Malignancies: Potentials for Targeted Therapy / G. Rebagay, S. Yan, C. Liu and N.K. Cheung // Front. Oncol. 2012. №2. Р. 34. https://doi.org/10.3389/fonc.2012.00034.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Therapeutic advances in the targeting of ROR1 in hematological cancers / A.B. Tigu, R. Munteanu, C. Moldovan [et al.] // Cell Death Discov. 2024. №10(1). Р. 471. https://doi.org/10.1038/s41420-024-02239-1.</mixed-citation><mixed-citation xml:lang="en">Therapeutic advances in the targeting of ROR1 in hematological cancers / A.B. Tigu, R. Munteanu, C. Moldovan [et al.] // Cell Death Discov. 2024. №10(1). Р. 471. https://doi.org/10.1038/s41420-024-02239-1.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lin W. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis / W. Lin, R. Niu, S.M. Park [et al.] // Nat Commun. 2023. №14(1). Р. 1578. https://doi.org/10.1038/s41467-023-37306-1.</mixed-citation><mixed-citation xml:lang="en">Lin W. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis / W. Lin, R. Niu, S.M. Park [et al.] // Nat Commun. 2023. №14(1). Р. 1578. https://doi.org/10.1038/s41467-023-37306-1 .</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu H. ROR1 facilitates glioblastoma growth via stabilizing GRB2 to promote c-Fos expression in glioma stem cells / H. Zhu, L. Cheng, D. Liu [et al.] // Neuro Oncol. 2025. № 27(3). Р. 695–710. https://doi.org/10.1093/neuonc/noae224.</mixed-citation><mixed-citation xml:lang="en">Zhu H. ROR1 facilitates glioblastoma growth via stabilizing GRB2 to promote c-Fos expression in glioma stem cells / H. Zhu, L. Cheng, D. Liu [et al.] // Neuro Oncol. 2025. № 27(3). Р. 695–710. https://doi.org/10.1093/neuonc/noae224.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jung M.S. The Role of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Cancer Stem Cell Signaling / M.S. Jung, W.Y. Choi, W. Zhang [et al.] // Int J Mol Sci. 2025. №26(16). Р. 7828. https://doi.org/10.3390/ijms2667828 . PMID : 40869147; PMCID : PMC12386924.</mixed-citation><mixed-citation xml:lang="en">Jung M.S. The Role of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Cancer Stem Cell Signaling / M.S. Jung, W.Y. Choi, W. Zhang [et al.] // Int J Mol Sci. 2025. №26(16). Р. 7828. https://doi.org/10.3390/ijms2667828  . PMID : 40869147; PMCID : PMC12386924.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Faust J.R. Mesothelin: An Immunotherapeutic Target beyond Solid Tumors / J.R Faust., D. Hamill, E.A. Kolb [et al.] // Cancers. 2022. №14. Р. 1550. https://doi.org/10.3390/cancers14061550.</mixed-citation><mixed-citation xml:lang="en">Faust J.R. Mesothelin: An Immunotherapeutic Target beyond Solid Tumors / J.R Faust., D. Hamill, E.A. Kolb [et al.] // Cancers. 2022. №14. Р. 1550. https://doi.org/10.3390/cancers14061550.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Boisgard R. Mesothelin biology and the evolving landscape of targeted immunotherapy / R. Boisgard, P. Chames, B. Kerfelec //Molecular Therapy Oncology. 2026. №34. Р. 1–6</mixed-citation><mixed-citation xml:lang="en">Boisgard R. Mesothelin biology and the evolving landscape of targeted immunotherapy / R. Boisgard, P. Chames, B. Kerfelec //Molecular Therapy Oncology. 2026. №34. Р. 1–6</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
